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KMID : 0604520140400010037
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Journal of the Society of Cosmetic Scientists of Korea
2014 Volume.40 No. 1 p.37 ~ p.44
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Simultaneous Analysis of Antimicrobial Three Straight Chain 1,2-alkanediols in Cosmetics by Gas Chromatography
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Lee Hoo-Seob
Lee Sang-Hun
Kim Eun-Juk
Chung Cheol-Hee
Pyo Hyeong-Bae
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Abstract
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Preservatives such as paraben, phenoxyethanol, and chlorphene are commonly used in cosmetics thanks tocheap price and good antiseptic effect. Recently, consumers’ concerns about their possible toxicity and skin irritationforced them to be replaced with straight 1,2-alkanediols. However, as the alkanediols may also irritate skin, limitedamount of them should be used in cosmetics. Three 1,2-alkanediols including 1,2-pentanediol, 1,2-hexanediol, and1,2-octanediol in cosmetics were analyzed simultaneously by gas chromatogrphy with flame ionization detector. As aresult of method validation, the specificity was confirmed by the calibration curves of 1,2-pentanediol, 1,2-hexanediol,and 1,2-octanediol showing good linearity correlation coefficient of above 0.999 over the concentration range of 100~ 1,200 μg/g. The limit of detection (LOD) and quantification (LOQ) of 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediolwere 31, 40, and 19 μg/g and 98, 108, and 57 μg/g, respectively. The precision (Repeatability) of the amountin cosmetics showed less than 2.0%. Relative Standard Deviation (% RSD) and the Accuracy (% recovery) of theamount in cosmetics showed 99.3 ~ 103.3, 99.4 ~ 106.7, 97.5 ~ 107.3% respectively. As a result, simultaneous analysis of antimicrobial three 1,2-alkanediols in cosmetics were possible. This method can be utilized in accurate quantitativeanalysis of 1,2-alkanediols in cosmetics.
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KEYWORD
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gas chromatography, pentanediol, octanediol, hexanediol, alkanediol
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